Base Deficit as a Predictor of Mortality in Sepsis and Septic Shock.

  • Laxman Bhusal DM Emergency Medicine Resident, Department of General Practice and Emergency Medicine, Tribhuvan University Teaching Hospital, Nepal.
  • Pratap Narayan Prasad Professor, Department of General Practice and Emergency Medicine, Tribhuvan University Teaching Hospital, Campus Chief, Maharajgung Medical Campus, Nepal
  • Yogendra Man Shakya Professor,Department of General Practice and Emergency Medicine HOD, Deprtment of General Practice and Emergency Medicine, IOM, Tribhuvan University
  • Ramesh Prasad Acharya Professor,Department of General Practice and Emergency Medicine, IOM, Tribhuvan University

Abstract

Introduction: Sepsis is a common problem encountered in the emergency room which needs to be intervened early. It is always difficult to have the quick prognostic marker of sepsis in busy emergency. So this study was conducted to determine whether base deficit can be used as an indicator of mortality among septic patients in emergency room set up like ours.

Methods: It was a hospital-based descriptive cross-sectional study done at Tribhuvan University Teaching Hospital, Kathmandu from March 2018 to December 2018.  Acute physiology and chronic health evaluation II score(APACHE II), Base deficit, Sequential Organ Failure Assessment(SOFA)score on first day of arrival in the emergency room were calculated. The association of 28-day outcome with Acute physiology and chronic Health Evaluation II score, Base deficit value and SOFA score were derived.

Results: Out of 229 patients with septic shock 62 died (27%) and among 71 patients without septic shock,12 died(16.9%) .Overall mortality was 24.66 %(n= 74).The area under the ROC curve for Base deficit(0.864;95% C.I.=0.822-0.906), APACHE II( 0.782;95%C.I=0.718-0.848;,SOFA(0.689;95% C.I=0.620-0.757) were greater than 0.7 except for SOFA which signifies these test to  have fair efficacy to predict mortality.

Conclusions: High base deficit value predicts mortality in patients with sepsis and septic shock.

Keywords: Base Deficit; Sepsis; Septic Shock, Predictor, Mortality

DOI: http://doi.org/10.3126/jkahs.v2i2.25166

Published
2019-07-28
How to Cite
1.
Bhusal L, Prasad P, Shakya Y, Acharya R. Base Deficit as a Predictor of Mortality in Sepsis and Septic Shock. JKAHS [Internet]. 28Jul.2019 [cited 17Nov.2019];2(2). Available from: https://www.jkahs.org.np/jkahs/index.php/jkahs/article/view/85