Antibiotic Profile of Extended Spectrum Beta Lactamase (ESBL) Escherichia coli from Clinical Samples

Authors

  • Mahesh Kumar Chaudhary Nepal Mediciti Hospital
  • Indrani Jadhav School of Life and Basic Sciences, Jaipur National University, Jaipur, India.

Keywords:

E.coli

Abstract

Background: Extended spectrum β-lactamases have addressed the serious challenges worldwide as a threat to favorable outcomes of treatment of common infections in community and hospital settings since it is found to be increasing trends of multidrug resistance. The present study was aimed to determine the antibiotic profile of multidrug resistant E.coli and status of ESBLs producing E.coli.

Methods: This was a cross-sectional study conducted over a period of 2 years (September 2017 to April 2019) at microbiology laboratory of Nepal Mediciti Hospital. A total of 16542 samples were processed. Various clinical samples were collected from both inpatients and outpatients aseptically and without contaminating skin commensals. Standard microbiological techniques were used for isolation and identification of pathogens. Extended spectrum beta-lactamases were phenotypically confirmed by combined disc method.

Results: Out of 1449 E.coli isolates, 323(22.29%) were found to be MDR E.coli. Isolation rate of ESBL producing E.coli (66.56%) were found to be high among MDR E.coli isolates.

Conclusion: There is increasing prevalence of ESBL producing E.coli. It is essential to monitor antibiotic susceptibility pattern and formulate antibiotic policy to prevent the spread of MDR and ESBL producers.

                                                                  

Keywords: E.coli, Extended spectrum β-lactamase, Multidrug resistant

                                                                  

Author Biography

Mahesh Kumar Chaudhary, Nepal Mediciti Hospital

1Jaipur National University,Jaipur,India,

and Department of Microbiology, Nepal Mediciti Hospital, Lalitpur, Nepal

 

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Published

2020-12-04

How to Cite

1.
Chaudhary MK, Jadhav I. Antibiotic Profile of Extended Spectrum Beta Lactamase (ESBL) Escherichia coli from Clinical Samples. Journal of Karnali Academy of Health Sciences [Internet]. 2020Dec.4 [cited 2024May6];3(2):102-10. Available from: https://www.jkahs.org.np/jkahs/index.php/jkahs/article/view/161

Issue

Vol. 3 No. 2 (2020): JKAHS; May-Aug Issue (8)

Section

Original Article

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